Chosen Solution

My Mac Mini (Mid 2010) has suddenly developed a hum it has never had before. I did a complete teardown to determine the cause. Its not the HDD, nor the optical drive (which I replaced with an SSD)… It is the fan! But why now? In the process of reassembling I found a torn rubber bolt gasket, like the kind you see in the three bolt holes of the fan unit. Since all those were intact, I don’t know what piece it came off of. I didn’t see anything else in the teardown that had one of those… and yet here is a torn one, and I have a rattle. Anyone no where it might have come from?

This looks like the isolation grommet that fits into the frame to support the HD. Review this IFIXIT guide: Mac Mini Mid 2010 Hard Drive Replacement. Jump down to Step 17 look at the second image and the text. Steal a grommet from the SSD frame as its not needed there as much as the HD.