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Of course looking for better speed. My question is: can I run the OSX and my programs on the added SSD and leave my internal HDD for storage? Thanks for the help!

In a word YES. However the BUS speed of the optical drive may not give you your expected results. The main drive is Serial ATA (3 Gb/s). I have not found the exact speed of the optical BUS. And I believe The optical drive was PATA, so you will already get a downgrade. You might be much happier going with a replacement 3.5 " SSHD. These have been very reliable and I generally see a perceived 50% increase in speed Here’s Apples discussion on the issue: https://discussions.apple.com/thread/401