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Strange Situation. On one of my Customer, I phone 6. Speaker option is grey out while making a call. I have reset the I phone but still the same. Check the Loud Speaker is working but the option is grey out. any inputs on this ?

Can you test if the proximity sensor is working? (Place phone near your ear and screen should turn off). Have you tried using earphones and see if the sound works through there during calls? Especially one with in-line microphone on it. Also check the screw holes on the logic board specifically at the screen FPC ribbon connectors on the logic board for any long screw damage. Usually you’ll see threaded marks in the screw hole or copper being exposed under a microscope.