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I just recently replaced the display and digitizer of an iPad mini and now have a large smudge where the screen and digitizer seem to touch, any fixes would be appreciated

When reassembling an iPad, you have to be very careful about fingerprints on all three surfaces. Replacement parts usually come with a thin plastic cover so you should only remove them at the very end of the process. Still, it’s easy to get a finger print on one of the surfaces. The best way to clean the LCD, which is scratches very easily is to use a Lenspen to wipe away any residue or oils. The same applies to the inside surface of the digitzier.