Chosen Solution
I recently had to change my wife’s screen and battery, in two separate occasions, and now the microphone, speakerphone speaker, HOME button and charger port will not work. I read on another post that it MIGHT be the home button causing the issue, but that was for a i4. I have disassembled the phone several times checking the wires, connectors and assembly of all the screws. I am missing one of the bottom screws that holds the phone together, could that be part of it? On a point, there is sound coming out of the telephone speaker, but not when put onto speakerphone. Thanks everyone!
Sounds like you have somehow ripped the charger port ribbon cable. Are you still able to charge the phone? Anyway it’s probably a good idea to try a replacement charging port / dock ribbon flex assembly. You can get the part from here: iPhone 5c Lightning Connector and Headphone Jack Guide to replace the part: iPhone 5c Lightning Connector Assembly Replacement Since the lightning connector has a connection to the home button via golden prongs, connects to the loudspeaker and has the bottom microphone attached to it and is used when earpiece speaker is used.